{"id":119365,"date":"2025-10-13T08:16:39","date_gmt":"2025-10-12T23:16:39","guid":{"rendered":"https:\/\/adtechmanagement.com\/minnadepr-column\/?p=119365"},"modified":"2025-10-13T08:16:39","modified_gmt":"2025-10-12T23:16:39","slug":"what-is-base-pair","status":"publish","type":"post","link":"https:\/\/adtechmanagement.com\/minnadepr-column\/2025\/10\/13\/what-is-base-pair\/","title":{"rendered":"\u5869\u57fa\u5bfe\u3068\u306f\uff1fDNA\u306e\u69cb\u9020\u30fb\u5f79\u5272\u30fb\u7a2e\u985e\u3092\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac"},"content":{"rendered":"

\u79c1\u305f\u3061\u306e\u4f53\u306e\u8a2d\u8a08\u56f3\u3068\u3082\u3044\u3048\u308bDNA\u306f\u3001\u975e\u5e38\u306b\u7cbe\u5de7\u306a\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u69cb\u9020\u306e\u4e2d\u3067\u7279\u306b\u91cd\u8981\u306a\u306e\u304c\u300c\u5869\u57fa\u5bfe\u300d\u3067\u3059\u3002\u5869\u57fa\u5bfe\u306f\u907a\u4f1d\u60c5\u5831\u3092\u6b63\u78ba\u306b\u4fdd\u5b58\u3057\u4f1d\u3048\u308b\u305f\u3081\u306e\u57fa\u672c\u5358\u4f4d\u3067\u3042\u308a\u3001\u751f\u547d\u306e\u6839\u5e79\u306b\u95a2\u308f\u308b\u5b58\u5728\u3067\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u5869\u57fa\u5bfe\u306e\u57fa\u672c\u7684\u306a\u610f\u5473\u304b\u3089\u7a2e\u985e\u3001\u5f79\u5272\u3001DNA\u69cb\u9020\u3068\u306e\u95a2\u4fc2\u3001\u3055\u3089\u306b\u306f\u5869\u57fa\u5bfe\u306b\u95a2\u3059\u308b\u7814\u7a76\u3084\u5fdc\u7528\u307e\u3067\u5e45\u5e83\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n

1. \u5869\u57fa\u5bfe\u306e\u57fa\u672c\u6982\u5ff5<\/h2>\n

1.1 \u5869\u57fa\u5bfe\u3068\u306f\u4f55\u304b<\/h3>\n

\u5869\u57fa\u5bfe\u3068\u306f\u3001DNA\u3084RNA\u306e\u4e2d\u3067\u7279\u5b9a\u306e2\u3064\u306e\u5869\u57fa\u304c\u6c34\u7d20\u7d50\u5408\u306b\u3088\u3063\u3066\u7d50\u5408\u3057\u305f\u3082\u306e\u3092\u6307\u3057\u307e\u3059\u3002DNA\u306f\u4e8c\u672c\u306e\u9577\u3044\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9396\u304b\u3089\u6210\u308a\u3001\u3053\u308c\u3089\u306e\u9396\u306f\u5869\u57fa\u5bfe\u306b\u3088\u3063\u3066\u4e92\u3044\u306b\u7d50\u3073\u3064\u304d\u3001\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u5869\u57fa\u5bfe\u306e\u898f\u5247\u7684\u306a\u7d50\u5408\u3053\u305d\u304c\u3001\u907a\u4f1d\u60c5\u5831\u306e\u5b89\u5b9a\u7684\u306a\u4fdd\u5b58\u3084\u6b63\u78ba\u306a\u8907\u88fd\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n

1.2 \u5869\u57fa\u3068\u306f\u4f55\u304b<\/h3>\n

\u5869\u57fa\u306fDNA\u3084RNA\u306e\u57fa\u672c\u5358\u4f4d\u3067\u3042\u308b\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u4e00\u90e8\u3067\u3001\u7a92\u7d20\u3092\u542b\u3080\u6709\u6a5f\u5316\u5408\u7269\u3067\u3059\u3002DNA\u306b\u5b58\u5728\u3059\u308b\u5869\u57fa\u306f\u3001\u30a2\u30c7\u30cb\u30f3\uff08A\uff09\u3001\u30c1\u30df\u30f3\uff08T\uff09\u3001\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u3001\u30b7\u30c8\u30b7\u30f3\uff08C\uff09\u306e4\u7a2e\u985e\u3067\u3059\u3002RNA\u3067\u306f\u30c1\u30df\u30f3\u306e\u4ee3\u308f\u308a\u306b\u30a6\u30e9\u30b7\u30eb\uff08U\uff09\u304c\u4f7f\u308f\u308c\u307e\u3059\u3002 <\/p>\n

2. \u5869\u57fa\u5bfe\u306e\u7a2e\u985e\u3068\u305d\u306e\u7279\u5fb4<\/h2>\n

2.1 Watson-Crick\u5869\u57fa\u5bfe\u306e\u6210\u7acb<\/h3>\n

DNA\u306e\u57fa\u672c\u7684\u306a\u5869\u57fa\u5bfe\u306f\u30a2\u30c7\u30cb\u30f3\u3068\u30c1\u30df\u30f3\u3001\u30b0\u30a2\u30cb\u30f3\u3068\u30b7\u30c8\u30b7\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u3059\u3002\u30a2\u30c7\u30cb\u30f3\uff08A\uff09\u306f\u30c1\u30df\u30f3\uff08T\uff09\u30682\u672c\u306e\u6c34\u7d20\u7d50\u5408\u3067\u7d50\u3073\u3064\u304d\u3001\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u306f\u30b7\u30c8\u30b7\u30f3\uff08C\uff09\u30683\u672c\u306e\u6c34\u7d20\u7d50\u5408\u3067\u5f37\u56fa\u306b\u7d50\u5408\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7279\u7570\u7684\u306a\u7d50\u5408\u69d8\u5f0f\u3092\u300c\u76f8\u88dc\u6027\u300d\u3068\u547c\u3073\u3001DNA\u306e\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u306e\u5b89\u5b9a\u6027\u3068\u6b63\u78ba\u306a\u907a\u4f1d\u60c5\u5831\u4f1d\u9054\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002 <\/p>\n

2.2 \u975e\u6a19\u6e96\u5869\u57fa\u5bfe\u3068\u30df\u30b9\u30de\u30c3\u30c1<\/h3>\n

\u6b63\u5e38\u306a\u5869\u57fa\u5bfe\u4ee5\u5916\u306b\u3001DNA\u8907\u88fd\u3084\u640d\u50b7\u306e\u904e\u7a0b\u3067\u975e\u6a19\u6e96\u7684\u306a\u5869\u57fa\u5bfe\uff08\u30df\u30b9\u30de\u30c3\u30c1\uff09\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u304c\u907a\u4f1d\u60c5\u5831\u306e\u5909\u7570\u3084\u7a81\u7136\u5909\u7570\u306e\u539f\u56e0\u3068\u306a\u308a\u3001\u7d30\u80de\u306f\u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\u6a5f\u69cb\u3067\u3053\u308c\u3092\u691c\u51fa\u3057\u4fee\u6b63\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n

2.3 RNA\u306b\u304a\u3051\u308b\u5869\u57fa\u5bfe<\/h3>\n

RNA\u3067\u306f\u30c1\u30df\u30f3\u306e\u4ee3\u308f\u308a\u306b\u30a6\u30e9\u30b7\u30eb\uff08U\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001RNA\u3067\u306f\u30a2\u30c7\u30cb\u30f3\uff08A\uff09\u304c\u30a6\u30e9\u30b7\u30eb\uff08U\uff09\u3068\u76f8\u88dc\u7684\u306b\u7d50\u5408\u3057\u307e\u3059\u3002RNA\u306e\u591a\u304f\u306f\u4e00\u672c\u9396\u3067\u3059\u304c\u3001\u4e00\u90e8\u3067\u306f\u5869\u57fa\u5bfe\u306b\u3088\u308b\u4e8c\u6b21\u69cb\u9020\u3092\u5f62\u6210\u3057\u3001\u6a5f\u80fd\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002 <\/p>\n

3. DNA\u306e\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u3068\u5869\u57fa\u5bfe\u306e\u95a2\u4fc2<\/h2>\n

3.1 \u4e8c\u91cd\u3089\u305b\u3093\u306e\u767a\u898b\u3068\u610f\u7fa9<\/h3>\n

1953\u5e74\u3001\u30b8\u30a7\u30fc\u30e0\u30ba\u30fb\u30ef\u30c8\u30bd\u30f3\u3068\u30d5\u30e9\u30f3\u30b7\u30b9\u30fb\u30af\u30ea\u30c3\u30af\u304cDNA\u306e\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u3092\u63d0\u5531\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30e2\u30c7\u30eb\u3067\u306f\u3001DNA\u306e\u4e8c\u672c\u9396\u306f\u5869\u57fa\u5bfe\u306e\u76f8\u88dc\u6027\u306b\u3088\u3063\u3066\u7d50\u5408\u3057\u3001\u87ba\u65cb\u72b6\u306e\u69cb\u9020\u3092\u4fdd\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u69cb\u9020\u306f\u907a\u4f1d\u60c5\u5831\u306e\u8907\u88fd\u3084\u8ee2\u5199\u306b\u304a\u3051\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u307e\u3057\u305f\u3002 <\/p>\n

3.2 \u6c34\u7d20\u7d50\u5408\u306e\u91cd\u8981\u6027<\/h3>\n

\u5869\u57fa\u9593\u306e\u6c34\u7d20\u7d50\u5408\u306fDNA\u306e\u5b89\u5b9a\u6027\u3092\u78ba\u4fdd\u3057\u3064\u3064\u3082\u3001\u8907\u88fd\u6642\u306b\u306f\u7c21\u5358\u306b\u5207\u65ad\u3067\u304d\u308b\u6027\u8cea\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u306e\u7279\u6027\u304cDNA\u306e\u8907\u88fd\u3084\u4fee\u5fa9\u3001\u907a\u4f1d\u60c5\u5831\u306e\u8ee2\u5199\u306b\u304a\u3044\u3066\u67d4\u8edf\u306a\u5bfe\u5fdc\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n

3.3 \u5869\u57fa\u5bfe\u306e\u76f8\u88dc\u6027\u304c\u4fdd\u8a3c\u3059\u308b\u907a\u4f1d\u60c5\u5831\u306e\u6b63\u78ba\u6027<\/h3>\n

\u5869\u57fa\u5bfe\u306e\u6b63\u78ba\u306a\u7d44\u307f\u5408\u308f\u305b\u306f\u3001DNA\u8907\u88fd\u6642\u306b\u65b0\u3057\u3044\u9396\u304c\u6b63\u3057\u304f\u4f5c\u3089\u308c\u308b\u57fa\u76e4\u3068\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u89aa\u9396\u306e\u30a2\u30c7\u30cb\u30f3\u306b\u306f\u5e38\u306b\u30c1\u30df\u30f3\u304c\u7d50\u5408\u3057\u3001\u3053\u306e\u30eb\u30fc\u30eb\u304c\u907a\u4f1d\u60c5\u5831\u306e\u8aa4\u4f1d\u9054\u3092\u9632\u304e\u307e\u3059\u3002 <\/p>\n

4. \u5869\u57fa\u5bfe\u306e\u751f\u7269\u5b66\u7684\u5f79\u5272<\/h2>\n

4.1 \u907a\u4f1d\u60c5\u5831\u306e\u7b26\u53f7\u5316<\/h3>\n

DNA\u306e\u5869\u57fa\u914d\u5217\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u30b3\u30fc\u30c9\u3068\u306a\u308a\u307e\u3059\u3002\u5869\u57fa\u5bfe\u306f\u3053\u306e\u60c5\u5831\u306e\u5b89\u5b9a\u3057\u305f\u4fdd\u6301\u3068\u8aad\u307f\u53d6\u308a\u3092\u652f\u3048\u308b\u9375\u3067\u3059\u3002 <\/p>\n

4.2 DNA\u8907\u88fd\u904e\u7a0b\u306b\u304a\u3051\u308b\u5869\u57fa\u5bfe\u306e\u5f79\u5272<\/h3>\n

DNA\u8907\u88fd\u3067\u306f\u30012\u672c\u9396\u304c\u5206\u96e2\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u9396\u306b\u76f8\u88dc\u7684\u306a\u65b0\u3057\u3044\u5869\u57fa\u304c\u7d50\u5408\u3057\u3066\u65b0\u305f\u306a\u9396\u304c\u5408\u6210\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u904e\u7a0b\u304c\u6b63\u78ba\u306b\u884c\u308f\u308c\u308b\u306e\u306f\u5869\u57fa\u5bfe\u306e\u76f8\u88dc\u6027\u306e\u304a\u304b\u3052\u3067\u3059\u3002 <\/p>\n

4.3 DNA\u4fee\u5fa9\u3068\u907a\u4f1d\u5b50\u5b89\u5b9a\u6027\u7dad\u6301<\/h3>\n

DNA\u640d\u50b7\u3084\u30df\u30b9\u30de\u30c3\u30c1\u304c\u767a\u751f\u3059\u308b\u3068\u3001\u7d30\u80de\u5185\u306e\u4fee\u5fa9\u6a5f\u69cb\u304c\u3053\u308c\u3092\u691c\u51fa\u3057\u4fee\u6b63\u3057\u307e\u3059\u3002\u5869\u57fa\u5bfe\u306e\u7570\u5e38\u306f\u7a81\u7136\u5909\u7570\u3084\u75be\u60a3\u306e\u539f\u56e0\u306b\u306a\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002 <\/p>\n

5. \u5869\u57fa\u5bfe\u306b\u95a2\u9023\u3059\u308b\u7814\u7a76\u3068\u6280\u8853<\/h2>\n

5.1 DNA\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\u6280\u8853<\/h3>\n

DNA\u306e\u5869\u57fa\u914d\u5217\u3092\u89e3\u6790\u3059\u308b\u6280\u8853\u306f\u3001\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u89e3\u660e\u3084\u75be\u60a3\u8a3a\u65ad\u306b\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u30b5\u30f3\u30ac\u30fc\u6cd5\u3084\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\u306f\u5869\u57fa\u914d\u5217\u306e\u9ad8\u901f\u89e3\u6790\u3092\u53ef\u80fd\u306b\u3057\u307e\u3057\u305f\u3002 <\/p>\n

5.2 \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u5869\u57fa\u5bfe\u306e\u5fdc\u7528<\/h3>\n

CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3067\u306f\u3001\u7279\u5b9a\u306e\u5869\u57fa\u5bfe\u3092\u72d9\u3044\u6483\u3061\u3057\u3066\u6539\u5909\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u75be\u60a3\u306e\u6cbb\u7642\u3084\u751f\u7269\u306e\u6539\u826f\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002 <\/p>\n

5.3 \u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3067\u306e\u5fdc\u7528\u4f8b<\/h3>\n

PCR\uff08\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc\uff09\u306f\u7279\u5b9a\u306e\u5869\u57fa\u914d\u5217\u3092\u5897\u5e45\u3059\u308b\u6280\u8853\u3067\u3001\u6cd5\u533b\u5b66\u3084\u75c5\u539f\u4f53\u691c\u51fa\u306b\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n

6. \u5869\u57fa\u5bfe\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u95a2\u9023\u7528\u8a9e<\/h2>\n

6.1 \u30cc\u30af\u30ec\u30aa\u30c1\u30c9<\/h3>\n

\u5869\u57fa\u3001\u7cd6\u3001\u30ea\u30f3\u9178\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u5206\u5b50\u3067\u3001DNA\u3084RNA\u306e\u57fa\u672c\u5358\u4f4d\u3067\u3059\u3002\u5869\u57fa\u5bfe\u306f\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u5869\u57fa\u540c\u58eb\u306e\u7d50\u5408\u3092\u6307\u3057\u307e\u3059\u3002 <\/p>\n

6.2 \u76f8\u88dc\u6027<\/h3>\n

\u7279\u5b9a\u306e\u5869\u57fa\u304c\u4ed6\u306e\u7279\u5b9a\u306e\u5869\u57fa\u3068\u3060\u3051\u7d50\u5408\u3059\u308b\u6027\u8cea\u3092\u8868\u3059\u8a00\u8449\u3067\u3001DNA\u8907\u88fd\u306e\u5fe0\u5b9f\u6027\u3092\u652f\u3048\u3066\u3044\u307e\u3059\u3002 <\/p>\n

6.3 \u4e8c\u672c\u9396DNA\u3068\u4e00\u672c\u9396DNA<\/h3>\n

DNA\u306f\u901a\u5e38\u4e8c\u672c\u9396\u3067\u3059\u304c\u3001\u8907\u88fd\u3084\u8ee2\u5199\u6642\u306b\u306f\u4e00\u6642\u7684\u306b\u4e00\u672c\u9396\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002 <\/p>\n

7. \u307e\u3068\u3081<\/h2>\n

\u5869\u57fa\u5bfe\u306fDNA\u306e\u57fa\u672c\u69cb\u9020\u3067\u3042\u308a\u3001\u907a\u4f1d\u60c5\u5831\u306e\u4fdd\u5b58\u3068\u4f1d\u9054\u306b\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u30a2\u30c7\u30cb\u30f3\u3068\u30c1\u30df\u30f3\u3001\u30b0\u30a2\u30cb\u30f3\u3068\u30b7\u30c8\u30b7\u30f3\u304c\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067DNA\u306e\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u304c\u5b89\u5b9a\u3057\u3001\u751f\u547d\u306e\u60c5\u5831\u304c\u6b63\u78ba\u306b\u4f1d\u308f\u308a\u307e\u3059\u3002\u8fd1\u5e74\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3084\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u767a\u5c55\u3082\u3001\u3053\u306e\u5869\u57fa\u5bfe\u306e\u6027\u8cea\u3092\u57fa\u76e4\u3068\u3057\u3066\u304a\u308a\u3001\u533b\u5b66\u3084\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u9032\u5c55\u306b\u5927\u304d\u304f\u8ca2\u732e\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u5869\u57fa\u5bfe\u306e\u7814\u7a76\u306f\u65b0\u3057\u3044\u767a\u898b\u3084\u6280\u8853\u9769\u65b0\u306e\u9375\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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